It has been estimated that 75-90% of all visits to primary care physicians are for stress-related problems. Arguably, North America's leading health problem, stress has been associated with impaired immune system resistance to viral-linked disorders, ranging from the common cold and herpes to AIDS and depression. Joseph Rochford, PhD arrived at the Douglas Institute in 1991 and since has been examining how antidepressants change behavioral and biological mechanisms involved in coping with stress.

Joseph Rochford and his team are investigating various animal models of acute and chronic stress with a view to understanding innate and learned coping strategies, as well as the therapeutic effectiveness of antidepressants in alleviating stress. Dr. Rochford is also actively involved in educational and training initiatives.