Major depression is quite prevalent in the general population and is clearly associated to important consequences in our society. Treatment with antidepressants remains the most common treatment for depressive episodes. In addition, antidepressants are among the most commonly prescribed medications in North America.

This research project will allow us to better understand how individuals suffering from major depression differentiate themselves in terms of their response to antidepressant treatment. As such, the focus will be on two commonly prescribed antidepressants, both of which are already available on the market, in order to compare the molecular markers which differentiate those who respond to antidepressant treatment and those who do not.