Centre intégré universitaire de santé et de services sociaux de l’Ouest-de-l’Île-de-Montréal
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Clinical Studies
Evaluation of neuromodulation in the treatment of refractory major depression

Principal investigator : Marcelo Berlim

Description of the study :

We aim to investigate the use of neuromodulation in the treatment of refractory major depression. We plan to use daily magnetic stimulation sessions to treat patients with refractory depression. To better target participants who can benefit from the use of neuromodulation tools, we wish to assess the impact of this treatment, combined with two magnetic resonance imaging scans to better target the use of neuromodulation in the treatment of refractory depression.

Financial compensations : yes
  • One daily magnetic stimulation session for 4 weeks for a total of 20 sessions. Each treatment last about 30 minutes.
  • Assessments by a psychiatrist before the treatment, after the treatment and 1 month after the end of the reatment.
  • 2 brain scans, one before and another after the treatment, lasting about 1:30 per scan.
  • Better evaluation of the impact of neuromodulation in the treatment of depression.
Risks and discomforts
  • Patients at risk for epilepsy are excluded
  • Some participants can report headaches or a heating feeling on the scalp during the neuromodulation sessions
Eligibility criteria :

  • Be aged 18 to 60 years
  • Not have abused alcohol or illicit drugs in the past 6 months
  • Not have an uncontrolled medical illness (e.g., lungs, heart, kidneys)
  • Having presented, for at least two months, with symptoms associated with a depressive episode such as significant sadness, hopelessness, lack of interest, feelings of guilt, significant problems with sleep, appetite, concentration, indecision, fatigue
  • Having tried at least 1 anti-depressant during the current depression episode
  • Be available for 3 interviews, for participating in a 4-week clinical trial involving daily (Monday to Friday) 40-minute sessions of neuromodulation treatment, and for 2 sessions of magnetic resonance imaging.
Information :

To participate in the study, please contact :

Maxime Pedneault
Research coordinator
Phone : 514-761-6131, ext. 3407

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